Microwave hyperthermia in the presence of gold nanoparticles: Preliminary results

Ahmad Shanei, Ameneh Sazgarnia, Elham Dolat, Leila Hojaji-Najafabadi, Mohammadreza Sehhati, Milad Baradaran-Ghahfarokhi

Abstract


Introduction: The aim of this study was to evaluate the effects of microwave (MW) hyperthermia in the presence of gold nanoparticles (GNPs) on melanoma cancer cells.
Materials and Methods: In vitro MW hyperthermia treatment were performed on melanoma cancer cells in the presence of GNPs. All required control groups were also considered. The study was conducted for GNPs with different sizes including; 40, 80, 120, 134, 160, and 200 μg/mL under 10, 15 and 20 min MW hyperthermia. MTT assay was performed in order to evaluate the effectiveness of the used therapeutic methods on cell survival. The repeated measure ANOVA method was used for statistical analysis using SPSS version 16.0. A significant level of 0.05 was considered to the tests.
Results: Results showed that, using the ANOVA test, there was a significant decrease in the cell survival following the MW hyperthermia treatment in the presence of 134 μg/mL GNPs (P < 0.001). The mean ± SD of cell’s survival treated at the presence of 134 μg/mL GNP was 75.6%±8.4%, 89.3%±5.1%, and 75.2%±8.2% for 10, 15, and 20 minutes MW irradiation, respectively. For the group that received GNP in the absence of MW hyperthermia the mean ± SD of cell’s survival was 93.3%±4.8%.
Conclusion: Results of this study showed that, MW hyperthermia with GNPs can be efficiently led to a decrease in survival rate of the melanoma cells. More follow up in vivo studies on mammalians are needed to investigate the potential of the presented method for clinical applications.

Keywords: Microwave hyperthermia, Gold nanoparticles, Melanoma, Cancer


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